[Alcohol action and activation of NF-kappa B]

Alcohol consumption causes expression of numerous genes. The transcription factor, nuclear factor-kappa B (NF-kappa B), is found in essentially all types of cells and is involved in activation of an exceptionally large number of genes in response to infections, inflammation, and other stressful situations requiring rapid reprogramming of gene expression. Therefore, gene expression caused by alcohol consumption could be regulated via active NF-kappa B. This review focuses on the NF-kappa B signaling pathway under alcohol consumption, especially by acute alcohol loading.