Related Experiment Video

Updated: Oct 1, 2026

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

[Acute phase proteins and recurrence of angina after effective coronary angioplasty]

I A Alekseeva, A A Liakishev, V A Tkachuk

    Terapevticheskii Arkhiv
    |June 5, 2002
    PubMed

    Insights

    Recurrent angina after coronary angioplasty can be predicted by C-reactive protein (CRP) levels. Initial and post-procedure CRP measurements are key indicators for predicting angina recurrence post-successful CA.

    Area of Science:

    • Cardiovascular Medicine
    • Biomarkers
    • Interventional Cardiology

    Context:

    • Coronary angioplasty (CA) is a common procedure for treating coronary artery disease.
    • Predicting angina recurrence after CA is crucial for patient management and outcomes.
    • Acute phase proteins, including C-reactive protein (CRP) and plasminogen activator inhibitor-1 (PAI-1), are implicated in cardiovascular events.

    Purpose:

    • To investigate the relationship between clinical characteristics, acute phase protein levels (fibrinogen, CRP, PAI-1), and angina recurrence after successful CA.
    • To identify independent predictors of angina recurrence following CA.

    Summary:

    • This study analyzed 53 patients post-successful CA, measuring fibrinogen, CRP, and PAI-1 levels pre-procedure and at various follow-up points.
    • While PAI-1 activity and CRP showed differences between groups, multifactor analysis identified initial and post-operative day 2 CRP levels as independent predictors of recurrent angina.
    • Patients were followed for 12 months, categorized into angina-free (n=37) and recurrent angina (n=16) groups.

    Impact:

    • Initial and early post-operative CRP levels can serve as valuable biomarkers for predicting angina recurrence after successful CA.
    • This finding may guide clinical decision-making and patient monitoring strategies post-angioplasty.
    • Understanding these predictive factors can lead to improved patient stratification and tailored therapeutic interventions.
    Abstract

    More Related Videos

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

    Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

    Published on: January 28, 2020

    Related Concept Videos

    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

    The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
    Angina II: Classification01:27

    Angina II: Classification

    Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    Angina IV: Management01:26

    Angina IV: Management

    IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
    Acute Coronary Syndrome I: Introduction01:30

    Acute Coronary Syndrome I: Introduction

    Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
    Acute Coronary Syndrome III: Diagnostic Studies01:30

    Acute Coronary Syndrome III: Diagnostic Studies

    Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...