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Probiotics in clinical conditions.

Philippe R Marteau1

  • 1Gastroenterology Department, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, 20 rue Leblanc, 75908 Paris, France. philippe.marteau@egp.ap-hop-paris.fr

Clinical Reviews in Allergy & Immunology
|June 5, 2002
PubMed
Summary

Probiotics, beneficial live microorganisms, show positive health effects across numerous clinical applications, from preventing antibiotic-associated diarrhea to managing inflammatory bowel disease. Rigorous studies confirm their efficacy and excellent safety profile for host physiology.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Gastroenterology

Background:

  • Probiotics are nonpathogenic microorganisms conferring health benefits.
  • Their pharmacological actions are increasingly studied.
  • Evidence for clinical efficacy is growing.

Purpose of the Study:

  • To summarize and comment on evidence for probiotic benefits in various clinical situations.
  • To assess the pharmacological approach to studying probiotics.
  • To discuss the safety of current probiotic formulations.

Main Methods:

  • Review of randomized controlled trials and meta-analyses.
  • Pharmacological evaluation of probiotic mechanisms.
  • Analysis of clinical data across diverse health conditions.

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Main Results:

  • Probiotics demonstrate efficacy in antibiotic-associated disorders, gastroenteritis, and traveler's diarrhea.
  • Positive effects observed in lactose intolerance, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).
  • Potential benefits noted for Helicobacter pylori, Clostridium difficile colonization, urogenital infections, allergies, vaccination, and cholesterol reduction.

Conclusions:

  • Probiotics offer significant therapeutic potential across a wide range of clinical conditions.
  • Randomized controlled trials and meta-analyses provide substantial evidence for their positive effects.
  • Current probiotics exhibit an excellent safety record.