Related Experiment Video
Updated: Aug 19, 2026

Laboratory Scale Production and Purification of a Therapeutic Antibody
Published on: January 24, 2017
Therapeutic monoclonal antibodies: trends in development and approval in the US
1Tufts Center for the Study of Drug Development, Boston, MA 02111, USA. janice.reichert@tufts.edu
Abstract:
Monoclonal antibodies have significant potential as therapeutic agents because of their ability to bind to specific antigens. To determine trends in the clinical development and approval processes for therapeutic mAbs, data on 199 mAbs that entered clinical study from 1980 to 2001 were collected and analyzed. Of the 199 mAbs, 75 are in clinical development, two are undergoing Food and Drug Administration (FDA) review, and 11 are FDA approved. Approval success rates for murine, chimeric and humanized mAbs, and clinical and approval phase lengths for mAbs, are presented. In addition, mAbs that are either in phase III, FDA-review, or are FDA approved for antineoplastic or immunological indications are described.
More Related Videos
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Hybridoma Technology
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Drug Products: Biologics, Biosimilars and Interchangeables
FDA Approved Drugs: Changes to Approved Drugs
Therapeutic Drug Monitoring: Overview and Classification

