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Related Experiment Videos

Ethanol consumption patterns and conditioned place preference in mice lacking preproenkephalin.

Heather N Koenig1, M Foster Olive

  • 1Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA.

Neuroscience Letters
|June 5, 2002
PubMed
Summary

The preproenkephalin (Penk) system does not influence how much ethanol mice voluntarily consume or find rewarding. Studies show Penk null mutant mice behave similarly to wildtypes regarding ethanol preference and reward.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Genetics

Background:

  • Endogenous opioid systems play a role in regulating ethanol consumption and reward.
  • The enkephalinergic opioid peptide system, specifically preproenkephalin (Penk), is a key component of these systems.
  • Understanding Penk's role is crucial for comprehending the neurobiological underpinnings of alcohol use disorders.

Purpose of the Study:

  • To investigate the specific role of the preproenkephalin (Penk) system in voluntary ethanol consumption.
  • To determine if the Penk system mediates the rewarding effects of ethanol.
  • To examine ethanol-induced conditioned place preference in mice lacking the Penk gene.

Main Methods:

  • Utilized a two-bottle choice paradigm to assess voluntary ethanol intake in wildtype and Penk null mutant mice.

Related Experiment Videos

  • Administered increasing concentrations of ethanol (2-10% v/v) to evaluate consumption patterns.
  • Assessed ethanol reward by measuring conditioned place preference after ethanol administration (2 g/kg i.p.).

    • Main Results:

    • No significant differences in voluntary ethanol consumption or preference were observed between wildtype and Penk null mutant mice.
    • Both genotypes exhibited similar conditioned place preference responses to ethanol.
    • These findings indicate a lack of involvement of the Penk system in these specific behaviors.

    Conclusions:

    • The preproenkephalin (Penk) system is not essential for regulating voluntary ethanol intake.
    • The Penk system does not appear to mediate the rewarding properties of ethanol.
    • These results suggest that other endogenous opioid pathways may be more critical for controlling ethanol-related behaviors.