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Sex differences in the incidence of total callosal agenesis in BALB/cCF mice
Alex C Manhães1, Alexandre E Medina, Sergio L Schmidt
1Laboratório de Neurofisiologia e Avaliação Neurocomportamental, Departamento de Ciências Fisiológicas, IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, Fundos, 5 andar, Rio de Janeiro 20.551-030, Brazil. amanhaes@uerj.br
Abstract:
Corpus callosum (CC) development and adult morphology seems to be affected by sex. Here we analyzed the incidence of total callosal agenesis in 341 adult male and 318 female BALB/cCF mice. This strain of mice presents total or partial callosal agenesis in approximately 20-30% of its population. No significant differences were found in overall distributions of CC lengths and in average callosal lengths (totally acallosal excluded) between male and female mice. However, a highly significant difference in the incidence of total callosal agenesis was demonstrated: 18% (n=56) of the female mice presented such trait as opposed to 10% of males (n=34). This last result suggests that sex is a relevant factor in callosal development in its earliest stages of formation.
