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AGEID: a database of aging genes and interventions
Matt Kaeberlein1, Beatrice Jegalian, Mitch McVey
1Longenity Inc., Medford, MA 02153, USA. matt@longenity.com
Mechanisms of Ageing and Development
|June 5, 2002
Summary
The Aging Genes/Interventions Database (AGEID) centralizes aging research findings. This resource aids scientists in comparing longevity genes and interventions across diverse organisms.
Area of Science:
- Gerontology
- Bioinformatics
- Genetics
Background:
- Aging research involves numerous studies measuring lifespan across various organisms.
- Identifying genes and interventions influencing lifespan is crucial for understanding aging.
- Existing data on aging experiments are often fragmented and difficult to access.
Purpose of the Study:
- To create a comprehensive, centralized database of experimental results related to aging.
- To catalog all published experiments measuring lifespan in any organism.
- To include data on genes affecting age-associated disorders like Alzheimer's and Parkinson's diseases.
Main Methods:
- Development of the Aging Genes/Interventions Database (AGEID).
- Inclusion of experimental results on lifespan measurements from published literature.
- Integration of information on genes impacting age-related diseases and longevity.
Main Results:
- AGEID provides formatted reports detailing experimental conditions, genetic or environmental perturbations, and lifespan effects.
- Each report includes gene function, role in longevity, protein homologs, and references.
- The database serves as a unified resource for aging research data.
Conclusions:
- AGEID facilitates the comparison of genes and interventions affecting lifespan across different species.
- This database aims to accelerate aging research by providing accessible, organized experimental data.
- AGEID supports researchers in identifying conserved mechanisms of aging and longevity.