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Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells

Veronika Thorns1, Gerhard Franz Walter, Federico Licastro

  • 1Department of Neuropathology, Medical School of Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Thorns.veronika@mh-hannover.de

Journal of Neuroimmunology
|June 5, 2002
PubMed

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...