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Related Experiment Videos

ATP-dependent nucleosome remodeling.

Peter B Becker1, Wolfram Hörz

  • 1Adolf-Butenandt-Institut, Molekularbiologie, 80336 Munich, Germany. pbecker@mol-bio.med.uni-muenchen.de

Annual Review of Biochemistry
|June 5, 2002
PubMed
Summary
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Nucleosome remodeling enzymes use ATP energy to alter DNA accessibility within cells. This review details their mechanisms, targeting, and integration into gene regulation.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genomics

Background:

  • Cellular genomes are organized into compact chromatin, posing a challenge for accessing genetic information.
  • Nucleosome remodeling enzymes, powered by ATP, are crucial for making DNA accessible within the nucleus.
  • These enzymes are part of a superfamily of ATPases and function within larger protein complexes.

Purpose of the Study:

  • To review recent advancements in understanding nucleosome remodeling.
  • To elucidate the mechanisms by which these enzymes alter chromatin structure.
  • To explore how remodeling complexes are targeted to specific DNA sites and integrated into regulatory networks.

Main Methods:

  • In vitro studies demonstrating enzyme activity on nucleosomal DNA.

Related Experiment Videos

  • Analysis of ATPase superfamily characteristics.
  • Integration of findings from diverse protein complex studies.

    • Main Results:

    • Nucleosome remodelers weaken DNA-histone octamer interactions, facilitating DNA sliding or displacement.
    • This process creates accessible DNA regions on nucleosomes.
    • The collective action of remodelers is presumed to confer dynamic properties to chromatin, influencing nuclear functions.

    Conclusions:

    • Nucleosome remodeling is a fundamental process for dynamic chromatin regulation.
    • Understanding remodeling mechanisms and targeting is key to deciphering gene accessibility.
    • These enzymes are integral components of complex cellular regulatory schemes.