Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic inflammatory demyelinating polyradiculoneuropathy.

John D Pollard1

  • 1Department of Medicine, Room 475, University of Sydney, D06 Blackburn, Sydney, NSW 2006, Australia. jdpoll@med.usyd.edu.au

Current Opinion in Neurology
|June 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis.

Frontiers in neurology·2021
Same author

Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation.

Frontiers in neurology·2020
Same author

The clinical profile of NMOSD in Australia and New Zealand.

Journal of neurology·2020
Same author

Anti-MAG neuropathy: Role of IgM antibodies, the paranodal junction and juxtaparanodal potassium channels.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2018
Same author

Neurofascin-155 IGG4 Neuropathy: Pathophysiological Insights, Spectrum of Clinical Severity and Response To treatment.

Muscle & nerve·2017
Same author

Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2017
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
Same journal

Functional movement disorders: diagnosis, pathophysiology, and treatment.

Current opinion in neurology·2026
Same journal

Investigational approaches to multiple sclerosis therapy.

Current opinion in neurology·2026
See all related articles

Chronic inflammatory demyelinating polyradiculopathy (CIDP) shows emerging subtypes. Research is defining diagnostic tools and understanding pathogenesis for targeted CIDP treatments.

Area of Science:

  • Neurology
  • Immunology
  • Neurophysiology

Background:

  • Chronic inflammatory demyelinating polyradiculopathy (CIDP) presents with emerging clinical subtypes, similar to Guillain-Barré syndrome.
  • Pathogenic mechanisms and specific treatments for CIDP subgroups remain undefined.
  • Distinguishing CIDP from IgM paraproteinemic neuropathy is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To explore diagnostic neurophysiological techniques for CIDP.
  • To investigate the role of magnetic resonance imaging (MRI) in CIDP diagnosis.
  • To elucidate the immunological and cellular basis of CIDP pathogenesis.

Main Methods:

  • Utilizing neurophysiological tests like terminal latency index and modified F ratio.
  • Employing magnetic resonance imaging (MRI) to visualize nerve changes.

Related Experiment Videos

  • Conducting immunohistological studies on nerve biopsies to analyze cellular markers and immune responses.

    • Main Results:

    • Neurophysiological methods effectively differentiate CIDP from IgM paraproteinemic neuropathy.
    • MRI reveals characteristic findings such as enlarged nerve roots and gadolinium enhancement in CIDP.
    • Immunohistology demonstrates T cell activation within nerves and identifies Schwann cells as antigen-presenting cells, suggesting localized immune responses.
    • Pathogenic antibodies were identified in a subset of CIDP patients.

    Conclusions:

    • Emerging CIDP subtypes require further investigation for tailored therapies.
    • Neurophysiology and MRI are valuable tools for diagnosing CIDP and differentiating it from other neuropathies.
    • Understanding the immunological underpinnings of CIDP, including T cell activation and Schwann cell antigen presentation, offers new therapeutic avenues.
    • Intravenous immunoglobulin and prednisone show short-term efficacy in CIDP treatment, warranting further study.