Related Experiment Video
Updated: Jul 10, 2026

Manipulating the Murine Lacrimal Gland
Published on: November 18, 2014
Evaluation of lacrimal system outflow in the newborn by dye tests
Silvana A. Schellini1, Erika Hoyama, Marielce C. Rocha
1Department of Ophthalmology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista-Botucatu, São Paulo State, Brazil
Abstract:
PURPOSE: The aim of this study was to evaluate the outflow from the lacrimal excretory system (LES) at birth. METHOD: Two-hundred LES were evaluated by the Milder Test (DDT) and the modified Jones I Test (JIT) in 100 newborns (NBs) from 31 (T1) until 42 (T3) weeks of gestational age. The occurrence of obstruction was related to sex, weight at birth, presence of ocular discharge and the degree of maturity. RESULTS: Both tests were in agreement and showed LES obstruction in 61.5% (DDT) and 78.5% (JIT), respectively, while the LES outflow increased with increasing maturity. CONCLUSION: Evaluation of LES outflow at birth reveals obstruction rates that are much higher than those clinically observed in children with complaints of epiphora.
More Related Videos
06:05Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
Published on: October 12, 2017
08:04A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
Published on: January 24, 2020