[Procoagulant activity of blood cells in pestivirus infection]

An increased level of procoagulant activity (PCA) in leukocytes of pigs with acute classical swine fever (CSF) was observed on day 4 postinfection; PCA level normalized during the moribund state. CSF vaccine strain either did not induce an increase of PCA level or induced an increase that persisted for at least 11 days. Time course of PCA changes in the leukocytes from sheep infected with borderline sheep disease was similar to the time course of PCA in acute CSF. In vitro each of the pestiviruses induced an increase in PCA in homologous and heterologous leukocytes.