[Sensitizing and virus-neutralizing characteristics of goat immunoglobulins to Ebola virus]

Sensitizing and virus-neutralizing properties of IgG isolated from the sera of goats immunized with Ebola virus and a relevant gammaglobulin prepared by ethanol fractionation were compared. The ratio of the virus-neutralizing activities of subclasses IgG2, IgG1a, and IgG1b was 100:10:1. Anaphylactogenic activity of IgG2 in the immediate type hypersensitivity test in guinea pigs was 2-fold lower than that of IgG1a and IgG1b. Goat gammaglobulin to Ebola virus, consisting from IgG2 antibodies by more than 50%, possessed virus-neutralizing and sensitizing characteristics compatible to IgG2.