Methodology for the assessment of burden of smear-positive pulmonary TB and its infectivity
Qun Xu1, Zheng-Lai Wu, Xiao-Lin Liu
1Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sicences, Beijing 100005, China.
Objective:
The study investigated the burden of smear-positive pulmonary TB and its infectivity using DALY (disability-adjusted life year) as an indicator.
Methods:
An assumed cohort of 2,000 cases was set up based on the age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity under natural history and DOTS(directly observed treatment, short-course) strategy were established according to the epidemiological evidence.
Results:
The results showed that 29.6% of DALYs would be neglected if the burden caused by the infectivity was not considered.
Conclusion:
DOTS strategy may reduce 97.3% of the number of potential cases infected, 92.9% of DALYs related to TB-patients themselves, and 99.9% of DALYs caused by TB's infectivity as well.
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