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Updated: Sep 30, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
Published on: June 13, 2011
A polymorphism in the interleukin-1alpha gene influences the clinical features of migraine
Innocenzo Rainero1, Lorenzo Pinessi, Giuliana Salani
1Neurology III, Headache Center, Department of Neuroscience, University of Torino, Italy.
Objective:
To evaluate whether a particular genotype of the interleukin-1alpha (IL1A) gene affects the clinical features of migraine.
Background:
Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin-1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases.
Methods:
In a group of 269 patients with migraine, we tested the association of the -889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease.
Results:
Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly (P <.01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly (P <.05) more frequent in patients with migraine with aura than in patients with migraine without aura.
Conclusions:
The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.
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