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Related Experiment Videos

Hydrogels: from controlled release to pH-responsive drug delivery.

Piyush Gupta1, Kavita Vermani, Sanjay Garg

  • 1National Institute of Pharmaceutical, Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India.

Drug Discovery Today
|June 6, 2002
PubMed
Summary

Hydrogels are advanced polymer systems for controlled drug delivery. This review focuses on pH-responsive hydrogels, highlighting their stimuli-responsive drug release capabilities for targeted applications.

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Area of Science:

  • Polymer science and materials science, focusing on drug delivery systems.

Background:

  • Hydrogels are emerging polymer-based systems for controlled drug delivery.
  • They offer swelling-controlled drug release and stimuli-responsive network changes affecting release rates.
  • Physiological pH variations across body sites drive interest in pH-responsive systems.

Purpose of the Study:

  • To review the application of hydrogels in controlled drug delivery.
  • To highlight stimuli-responsive drug release from hydrogels, with a specific focus on pH-responsive systems.

Main Methods:

  • Literature review of hydrogel applications in controlled drug delivery.
  • Analysis of stimuli-responsive mechanisms, particularly pH-responsiveness.

Main Results:

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  • Hydrogels demonstrate tunable drug release based on swelling and network properties.
  • pH-responsive hydrogels exhibit significant potential due to physiological pH variations.
  • These systems offer controlled release profiles influenced by environmental pH.

    • Conclusions:

    • Hydrogels are versatile polymeric systems for advanced drug delivery.
    • Stimuli-responsive hydrogels, especially pH-responsive ones, are crucial for targeted and controlled therapeutic release.