Neurophysiological correlate of clinical signs in Parkinson's disease

Clinical diagnosis of Parkinson's disease (PD) is not always coincident with pathological findings. A better characterization of the disease from the results of studies in various areas of neuroscience can help in improving the rate of diagnostic certainty. Neurophysiology is among the techniques with better chances to furnish specific diagnostic cues on motor aspects of the disease. Neurophysiology provides quantifiable data using non-invasive, relatively inexpensive, methods. Neurophysiological tests can be applied with no previous preparation, and repeated many times without dangerous consequences. To be rewarding, however, neurophysiological examination should be done in close cooperation between the clinician who detects relevant specific signs, and the neurophysiologist who devises the most demonstrative methods to document those signs. In this review, we describe the neurophysiological correlate of symptoms and signs in patients with PD, and particularly their pathophysiological meaning, with special focus on those that could be more helpful to the neurologists in establishing differences with respect to other diseases presenting with parkinsonism.