[Ultrastructural study of the activity of phospholipids in experimental liver damage induced by isoniazide]

The authors studied the activity of egg-derived phospholipids on the hepatotoxic effect induced in rats by isoniazid (INH) given orally for 20 consecutive days in doses of 25, 50 and 100 mg/kg/day. In the animals treated with the highest dose of INH, a great number of liver cells showed structural and ultrastructural changes. Their hyaloplasm was more electron-dense, the cytoplasmic structure was condensed and collapsed, without apparent endoplasmic reticulum and ribosomes. A very different structural and ultrastructural picture was observed in the animals treated with INH + phospholipids. The structure was quite normal without degenerating cells. There was a greater richness of endoplasmic reticulum, ribosomes and glycogen particles.