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Orbital giant cell fibroblastoma
Gregory Carroll1, Barrett G. Haik, Zeynel A. Karcioglu
1University of Tennessee Medical School, Memphis, Tennessee, USA
Orbit (Amsterdam, Netherlands)
|June 6, 2002
Summary
Orbital giant cell fibroblastoma, a rare benign tumor, presents challenges due to its invasive nature. This case highlights its unique clinical and morphologic features in an adult orbital region.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Giant cell fibroblastoma is a rare benign mesenchymal tumor typically seen in infants.
- This tumor has not been previously reported in the ophthalmological literature.
Purpose of the Study:
- To describe the clinical and morphologic features of an orbital giant cell fibroblastoma.
- To document the first reported case in the ophthalmological literature.
Main Methods:
- Review of clinical symptoms, computed tomography (CT), and magnetic resonance (MR) imaging.
- Histopathologic examination including light and electron microscopy and immunohistochemistry.
Main Results:
- A 65-year-old woman presented with a large, infiltrating orbital mass causing proptosis and visual loss.
- Imaging revealed an irregular orbital mass with globe displacement.
- Histopathology showed a mixture of spindle cells, multinucleated giant cells, and a myxomatous stroma.
Conclusions:
- Orbital giant cell fibroblastoma is a rare entity in the orbital region, even in adults.
- Despite being benign and non-metastasizing, its invasive nature and potential for recurrence pose significant clinical management challenges.