[Experimental-clinical basis for using sporobacterin in the combined treatment of pancreonecrosis]

Experimental investigations on translocation of the intestinal microflora on the model of acute pancreatitis were performed in 54 animals (albino rats) and showed an increased bacterial dissemination of parenchymatous organs of the abdominal cavity as the inflammatory and destructive alterations increased in the pancreas. E. coli aggravated the inflammatory alterations in the pancreas while B. subtilis promoted reparative processes. Experimental substantiation is given to using sporobacterin in the complex postoperative treatment of patients with pancreatonecrosis.