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Related Experiment Videos

[Infection and rejection].

Takahito Yagi1, Noriaki Tanaka

  • 1Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.

Nihon Geka Gakkai Zasshi
|June 7, 2002
PubMed
Summary
This summary is machine-generated.

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Living donor liver transplantation (LDLT) shows a high survival rate. Early detection of severe acute rejection using Doppler ultrasonography (US) and programmed pulse therapy can improve patient outcomes in LDLT.

Area of Science:

  • Hepatobiliary Surgery
  • Transplant Immunology
  • Diagnostic Imaging

Context:

  • Living donor liver transplantation (LDLT) is a critical procedure for end-stage liver disease.
  • Optimizing post-transplant management, including infection and rejection monitoring, is essential for patient survival.
  • Tacrolimus-based immunosuppression is standard, but acute rejection remains a significant challenge.

Purpose:

  • To analyze outcomes, including survival rates, postoperative infections, and rejection episodes, in a cohort of LDLT recipients.
  • To investigate the utility of routine Doppler ultrasonography (US) in identifying early, severe acute rejection.
  • To evaluate the effectiveness of programmed pulse therapy in managing acute rejection in LDLT.

Summary:

  • A study of 41 LDLT recipients reported a 90.2% survival rate, with manageable infection rates.

Related Experiment Videos

  • Despite standardized immunosuppression, 46.3% experienced rejection episodes; 2 recipients died from refractory rejection.
  • Routine Doppler US identified severe rejection with hemodynamic changes, characterized by shorter onset, worse histology, and elevated ALT levels, suggesting its diagnostic value.

    • Impact:

    • Routine Doppler US combined with programmed pulse therapy may enhance the early diagnosis and treatment of severe acute rejection in LDLT.
    • This approach could potentially reduce the morbidity and mortality associated with acute rejection after liver transplantation.
    • Findings support the integration of advanced imaging and targeted therapy for improved LDLT patient management.