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Synthesis and antioxidant activity of 3-substituted guaiazulene derivatives
Harris Pratsinis1, Serkos A Haroutounian
1Laboratory of Cell Proliferation and Ageing, Institute of Biology, NCSR Demokritos, Athens, Greece.
Natural Product Letters
|June 7, 2002
Abstract:
A series of 3-substituted guaiazulene derivatives has been synthesized and their antioxidant properties were evaluated by monitoring their capacity for scavenging the stable free-radical DPPH. 3-Vinylguaiazulene was the most potent, possessing antioxidant activity superior than alpha-tocopherol. These derivatives were also moderate inhibitors of the proliferation of human promyelocytic leukemia cells.