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Neurogenic appendicopathy: a clinical disease entity?
C Franke1, C D Gerharz, H Böhner
1Department of General and Trauma Surgery, Heinrich Heine University, Düsseldorf, Germany. Claus.Franke@med.uni-duesseldorf.de
International Journal of Colorectal Disease
|June 7, 2002
Summary
Neurogenic appendicopathy (NA) is a histopathological entity identifiable with hematoxylin-eosin staining. Clinical evaluation cannot reliably distinguish NA from acute appendicitis or negative appendectomies preoperatively.
Area of Science:
- Gastrointestinal Pathology
- Surgical Pathology
- Histopathology
Background:
- Neurogenic appendicopathy (NA) is a condition affecting the appendix.
- Its distinct clinical entity and diagnostic methods require clarification.
- Understanding NA's prevalence and differentiation from acute appendicitis is crucial.
Purpose of the Study:
- To compare two histopathological staining methods for diagnosing NA.
- To determine the frequency of NA in patients undergoing appendectomy.
- To assess if NA is clinically distinct from acute appendicitis.
Main Methods:
- A prospective, observational, multicenter study involving 282 patients who had appendectomies.
- Comparison of hematoxylin-eosin staining with S-100 staining for NA diagnosis.
- Evaluation of NA frequency in acute appendicitis and negative appendectomy groups.
Main Results:
- Hematoxylin-eosin staining showed 93% accuracy compared to S-100 staining for NA diagnosis.
- NA was found in 3.8% of acute appendicitis cases and 47% of negative appendectomies.
- Significant differences between NA, acute appendicitis, and negative appendectomy groups were limited.
Conclusions:
- Neurogenic appendicopathy is a histopathological entity diagnosable with hematoxylin-eosin staining.
- Preoperative clinical history and examination are insufficient to differentiate NA from acute appendicitis or negative appendectomy.