Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new particulate antigen present in serum.

Y E Cossart

    Developments in Biological Standardization
    |January 1, 1975
    PubMed
    Summary

    A novel antigen, distinct from Australia antigen, was identified in blood donors. This antigen comprises small spherical particles and is associated with a widespread antibody in the population.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The current pattern of hepatitis B virus infection in Australia.

    Journal of viral hepatitis·2006
    Same author

    Risk of hepatitis C virus infection in multiply transfused premature neonates.

    Journal of paediatrics and child health·2001
    Same author

    Variable oncogene promoter activity of human papillomavirus type 16 cervical cancer isolates from Australia.

    Journal of clinical microbiology·2001
    Same author

    Squamous carcinoma of the head and neck: molecular mechanisms and potential biomarkers.

    The Australian and New Zealand journal of surgery·2000
    Same author

    Analysis of mutations in the URR and E6/E7 oncogenes of HPV 16 cervical cancer isolates from central China.

    International journal of cancer·2000
    Same author

    Hepatitis C in injecting drug-using women during and after pregnancy.

    Journal of gastroenterology and hepatology·2000

    Area of Science:

    • Immunology
    • Virology
    • Blood Transfusion Medicine

    Background:

    • The identification of new antigens in human serum is crucial for understanding immune responses and transfusion safety.
    • Australia antigen is a well-known hepatitis B virus surface antigen, and its discovery revolutionized viral hepatitis research.

    Purpose of the Study:

    • To characterize a newly discovered antigen found in the serum of blood donors.
    • To determine the physical properties and prevalence of the corresponding antibody for this new antigen.

    Main Methods:

    • Serum samples from 10 blood donors were analyzed for the presence of a novel antigen.
    • Electron microscopy was used to determine the morphology and size of the antigen particles.
    • Serological assays were performed to assess the distribution of the corresponding antibody in the general population.

    Main Results:

    • A new antigen, distinct from Australia antigen, was detected in 10 blood donor samples.
    • The antigen is composed of spherical particles measuring 21-23 nm in diameter.
    • The antibody against this new antigen was found to be widely distributed among the population.

    Conclusions:

    • A previously unrecognized antigen exists in the blood donor population.
    • The physical characteristics suggest a potential viral or proteinaceous nature.
    • The widespread presence of the antibody indicates significant prior exposure within the population, warranting further investigation into its clinical significance.

    Related Experiment Videos