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Implication of immunological abnormalities after adenotonsillotomy.
Beata Zielnik-Jurkiewicz1, Dariusz Jurkiewicz
1Department of Otolaryngology, Children's Hospital, 02-970 Warsaw, Zapłocie 42C, Poland. bzielnik@lekarz.net
Summary
Children with enlarged adenoids and tonsils show altered immune responses. Adenotonsillotomy temporarily impacts immunity, but parameters normalize within six months, highlighting the need for pre-operative immune assessment.
Area of Science:
- Immunology
- Otolaryngology
- Pediatrics
Background:
- Adenoids and tonsils are key lymphoid organs in upper respiratory tract defense.
- Hypertrophy of these tissues can impact immune system function.
- Understanding immune changes in children with hypertrophy is crucial.
Purpose of the Study:
- To investigate systemic immunity changes in children with adenoid and tonsil hypertrophy.
- To assess the impact of adenotonsillotomy on immunological parameters.
- To determine the necessity of pre-operative immunological evaluation.
Main Methods:
- Study included 80 children with hypertrophy and 40 controls.
- Assessed serum immunoglobulin levels (IgA, IgG, IgM) for humoral immunity.
- Evaluated T lymphocyte subsets (CD3, CD4, CD8) and cell-mediated immunity (Multitest CMI).
Main Results:
- Children with hypertrophy exhibited altered immunological parameters.
- Adenotonsillotomy led to a significant early decrease in humoral and cellular immunity.
- Immune parameters normalized six months post-surgery.
Conclusions:
- Hypertrophy of adenoids and tonsils affects both local and systemic immunity.
- Pre-operative assessment of humoral and cellular immunity is recommended before adenotonsillotomy.