Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EMBL-Align: a new public nucleotide and amino acid multiple sequence alignment database.

V Lombard1, E B Camon, H E Parkinson

  • 1EMBL Outstation The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. align@ebi.ac.uk

Bioinformatics (Oxford, England)
|June 7, 2002
PubMed
Summary

The European Bioinformatics Institute developed EMBL-Align, a new public database for multiple sequence alignments, and Webin-Align, a submission tool. This addresses the growing challenge of archiving vast amounts of alignment data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An enhanced workflow for variant interpretation in UniProtKB/Swiss-Prot improves consistency and reuse in ClinVar.

Database : the journal of biological databases and curation·2019
Same author

Feature extraction and signal processing for nylon DNA microarrays.

BMC genomics·2004
Same author

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.

Nature genetics·2001
Same author

Accessing and distributing EMBL data using CORBA (common object request broker architecture).

Genome biology·2001
Same author

Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures.

Molecular and cellular biology·2000
Same author

The EMBL Nucleotide Sequence Database. Contributing and accessing data.

Molecular biotechnology·2000

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • The European Molecular Biology Laboratory (EMBL) has experienced a 30-fold increase in multiple sequence alignment submissions over the last decade.
  • This surge in data presents significant archiving and management challenges.

Purpose of the Study:

  • To introduce EMBL-Align, a new public database for managing multiple sequence alignment data.
  • To present Webin-Align, a dedicated web-based submission tool designed to streamline the submission process.

Main Methods:

  • Development of a new public database, EMBL-Align, for storing multiple sequence alignments.
  • Implementation of Webin-Align, a web-based tool for data submission, accepting common alignment formats.
  • Integration with the European Molecular Biology Laboratory's Sequence Retrieval System (SRS) for data querying.

Related Experiment Videos

Main Results:

  • EMBL-Align provides a comprehensive solution for the archiving and management of multiple sequence alignment data.
  • Webin-Align supports various common alignment formats and can output data in CLUSTALW and a new EMBL-Align flat file format.
  • Stored alignments are accessible via the European Molecular Biology Laboratory's Sequence Retrieval System (SRS).

Conclusions:

  • EMBL-Align and Webin-Align offer a robust system for handling the increasing volume of multiple sequence alignment data.
  • These tools enhance data accessibility and management within the bioinformatics community.
  • The new system facilitates efficient archiving and retrieval of crucial alignment information.