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ENDscript: a workflow to display sequence and structure information.

Patrice Gouet1, Emmanuel Courcelle

  • 1Laboratoire de Bio-Cristallographie, IBCP-CNRS UMR 5086, 7 passage du Vercors, 69367 Lyon Cedex 07, France. p.gouet@ibcp.fr

Bioinformatics (Oxford, England)
|June 7, 2002
PubMed
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ENDscript is a web server that integrates popular bioinformatics tools. It visualizes protein structure data, aiding researchers in understanding 1D, 2D, and 3D protein information.

Area of Science:

  • Bioinformatics
  • Structural Biology
  • Computational Biology

Background:

  • Web server integrating popular bioinformatics tools like BLAST, Multalin, and DSSP.
  • Utilizes Protein Data Bank (PDB) coordinate files as input.

Purpose of the Study:

  • To provide a unified platform for analyzing protein structure and sequence data.
  • To facilitate the visualization of conserved residues, secondary structures, accessibility, hydropathy, and intermolecular contacts.

Main Methods:

  • Input: Protein Data Bank (PDB) coordinate files.
  • Processing: Multiple sequence alignment against homologous sequences.
  • Output: Generation of PostScript and PNG figures.

Main Results:

Related Experiment Videos

  • Visualizes conserved residues from multiple sequence alignments.
  • Displays secondary structure elements, accessibility, and hydropathy.
  • Illustrates intermolecular contacts within protein structures.

Conclusions:

  • Enables rapid correlation of 1D, 2D, and 3D information for proteins with known structures.
  • Enhances the understanding of protein structure-function relationships through integrated visualization.