Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

FFA-induced endothelial dysfunction can be corrected by vitamin C.

Johannes Pleiner1, Georg Schaller, Friedrich Mittermayer

  • 1Department of Clinical Pharmacology, University of Vienna, Allgemeines Krankenhaus Wien, Währinger Gürtel 18-20, Vienna A-1090, Austria.

The Journal of Clinical Endocrinology and Metabolism
|June 7, 2002
PubMed
Summary

Elevated free fatty acids (FFAs) impair blood vessel function by increasing oxidative stress. Antioxidants like vitamin C can reverse this endothelial dysfunction, suggesting a therapeutic target for insulin resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.

Journal of hepatology·2020
Same author

Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals.

Scientific reports·2020
Same author

Impact of osteopontin on the development of non-alcoholic liver disease and related hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver·2020
Same author

Increased Release of Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NFĸB, p38, and ERK Pathways upon Omentin Treatment.

Obesity facts·2020
Same author

Associations between cognitive performance and Mediterranean dietary pattern in patients with type 1 or type 2 diabetes mellitus.

Nutrition & diabetes·2020
Same author

Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.

The Journal of clinical endocrinology and metabolism·2020

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Vascular Biology

Background:

  • Insulin resistance is linked to elevated plasma free fatty acids (FFAs) and endothelial dysfunction.
  • Free fatty acids may induce vascular impairment through the formation of reactive oxygen species.
  • Oxidative stress is a potential mechanism underlying FFA-induced endothelial dysfunction.

Purpose of the Study:

  • To investigate the role of free fatty acids in endothelial dysfunction.
  • To determine if vitamin C can mitigate FFA-induced endothelial dysfunction.
  • To assess the impact of FFAs on endothelium-dependent and independent vasodilation.

Main Methods:

  • Randomized, double-blind, cross-over study in 10 healthy volunteers.
  • Increased plasma FFAs induced by Intralipid/heparin infusion.

Related Experiment Videos

  • Forearm blood flow (FBF) responses to acetylcholine (ACh) and glyceryl trinitrate assessed with coadministration of vitamin C or placebo.

    • Main Results:

    • Elevated plasma FFAs significantly reduced FBF response to acetylcholine by 55%.
    • Vitamin C completely reversed the impaired FBF response to acetylcholine.
    • Vitamin C did not alter plasma FFA levels or affect glyceryl trinitrate responsiveness.

    Conclusions:

    • FFA-induced vascular oxidative stress contributes to endothelial dysfunction.
    • Antioxidants can reverse the local effects of FFAs on endothelium-dependent vasodilation.
    • These findings suggest a potential therapeutic strategy for insulin resistance-related vascular impairment.