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Updated: Oct 1, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
Carmen P Alvarez1, Fátima Lasala, Jaime Carrillo
1Laboratory of Molecular Microbiology, Dept. of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain.
Abstract:
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
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