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[Lipid profile in hematologic neoplasms].

Caterina Musolino1, Luana Calabrò, Giacomo Bellomo

  • 1Divisione di Ematologia, Dipartimento di Medicina Interna, Università, Messina. camilla.si@tiscalinet.it

Recenti Progressi in Medicina
|June 8, 2002
PubMed
Summary

Altered lipid profiles, including lower cholesterol and HDL-C, are common in hematologic neoplasms. These lipid changes may serve as valuable prognostic markers for cancer patients.

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Area of Science:

  • Oncology
  • Hematology
  • Clinical Biochemistry

Context:

  • Abnormal blood lipid profiles are frequently observed in patients with various human malignancies.
  • Tumoral cell metabolism is likely involved in these alterations.
  • Hematologic neoplasms represent a significant group of cancers where lipid metabolism may be dysregulated.

Purpose:

  • To investigate the clinical and biological implications of altered lipid profiles in patients with hematologic malignancies.
  • To evaluate the relationship between lipid profiles and established prognostic markers in oncohematologic patients.

Summary:

  • This study analyzed plasma lipids, lipoproteins, and apolipoproteins in 48 previously untreated oncohematologic patients across different subtypes (multiple myeloma, lymphoma, leukemia).

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  • Significantly reduced levels of cholesterol, HDL-C, and apo A were observed in these patients compared to reference values.
  • No correlation was found between cholesterol levels and tumor burden markers (LDH, beta-2-microglobulin, sICAM1), but increased cholesterol correlated with treatment response.

    • Impact:

    • The findings suggest that cholesterol, its fractions, and apolipoproteins can serve as useful biochemical and prognostic indicators in hematologic neoplasms.
    • Monitoring lipid profiles may offer insights into disease status and treatment efficacy in oncohematologic patients.
    • This research contributes to understanding the metabolic alterations in cancer and their potential as biomarkers.