Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The immunopathogenesis of multiple sclerosis.

Elisabetta Prat1, Roland Martin

  • 1Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA.

Journal of Rehabilitation Research and Development
|June 8, 2002
PubMed
Summary

Multiple sclerosis (MS) is an autoimmune disease involving T cells, likely triggered by environmental factors and specific genes. Research suggests myelin-specific CD4 T cells drive central nervous system invasion and disease initiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic immune tolerance for central nervous system autoimmune diseases - Prospects, challenges and pitfalls.

Seminars in immunology·2026
Same author

Distinct Clinico-pathogenic Subgroups in Pediatric Lyme Neuroborreliosis.

Open forum infectious diseases·2026
Same author

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis.

Cell·2026
Same author

EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation.

Cell·2026
Same author

Protocol for the characterization of autoproliferating B and T cells from persons with multiple sclerosis.

STAR protocols·2025
Same author

HLA Ligand Atlas DIA: extending the benign immunopeptidomics resource with increased sensitivity through data-independent acquisition mass spectrometry.

Journal for immunotherapy of cancer·2025

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Genetics

Background:

  • Multiple sclerosis (MS) is a T cell-mediated autoimmune disease.
  • Genetic susceptibility is linked to the major histocompatibility complex class II region.
  • An infectious etiology for MS is proposed, potentially shaping immune responses to self-antigens.

Purpose of the Study:

  • To explore the heterogeneous genetic and infectious factors contributing to MS pathogenesis.
  • To understand the role of myelin-specific CD4 T cells in disease initiation and progression.
  • To investigate the distinct mechanisms of injury in different MS patient subgroups.

Main Methods:

  • Analysis of major histocompatibility complex class II genes.
  • Investigation of potential infectious triggers.

Related Experiment Videos

  • Examination of myelin-specific CD4 T cell activity.
  • Study of MS lesion composition and tissue damage patterns.
  • Review of data from animal models and pharmacological studies.

    • Main Results:

    • Consistent association of MHC class II genes with MS susceptibility.
    • Evidence suggesting epistatic interactions among susceptibility genes.
    • Identification of myelin-specific CD4 T cells as key mediators of CNS invasion.
    • Observation of diverse tissue damage patterns in active MS lesions.
    • Clinical and imaging heterogeneity supports distinct disease mechanisms.

    Conclusions:

    • MS pathogenesis is complex, involving genetic predisposition, potential infectious agents, and T cell-mediated autoimmunity.
    • Heterogeneity in MS suggests distinct disease subtypes requiring tailored therapeutic approaches.
    • Advancements in gene expression profiling, proteomics, and imaging hold promise for identifying biomarkers and developing personalized therapies.