Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endocannabinoids in pain modulation.

J M Walker1, S M Huang

  • 1Department of Psychology, Brown University, 89 Waterman Street, Providence, RI 02912, USA. j.walker@brown.edu

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|June 8, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

World's Columbian Dental Congress-1893: Scientific Work by Sections.

The Dental register·2021
Same author

World's Columbian Dental Congress-1893: Scientific Work by Sections.

The Dental register·2021
Same author

The Alabama Dental Association.

The Dental register·2021
Same author

Mississippi State Dental Association, 1893.

The Dental register·2021
Same author

Georgia State Dental Society.

The Dental register·2021
Same author

World's Columbian Dental College-1893: Scientific Work by Sections.

The Dental register·2021
Same journal

Cardiovascular safety profile of prostaglandin E and prostacyclin analogues: Clinical reports and ex vivo studies on human coronary arteries.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same journal

Specialized pro-resolving mediator (SPM)-enriched supplementation modulates inflammatory biomarkers in patients with symptomatic knee osteoarthritis: Blood plasma analysis from the GAUDI study.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same journal

Serum fatty acid distributions and prevalence of low omega-3 status in early pregnancy: A cross-sectional analysis of 26,389 samples from an omega-3 test-and-treat program.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same journal

Association of fish intake with systemic immune-inflammation index: Potential mediating role of n-3 polyunsaturated fatty acids.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same journal

A novel algae oil-based emulsion enhances chemotherapy outcome in human cancer models.

Prostaglandins, leukotrienes, and essential fatty acids·2026
Same journal

Human milk omega-3 PUFA and infant neurodevelopment: Evidence and insights from indian mothers.

Prostaglandins, leukotrienes, and essential fatty acids·2026
See all related articles

Endocannabinoids play a key role in pain modulation, functioning similarly to endogenous opioids but through distinct mechanisms. Research confirms their involvement in controlling pain sensitivity.

Area of Science:

  • Neuroscience
  • Pain Management
  • Endocannabinoid Research

Background:

  • The endocannabinoid system is implicated in pain modulation.
  • Understanding its precise role is crucial for developing new pain therapies.

Purpose of the Study:

  • To elucidate the function of endocannabinoids in pain modulation.
  • To compare endocannabinoid mechanisms with those of endogenous opioids.

Main Methods:

  • Investigated endocannabinoid system markers in pain-controlling brain regions.
  • Administered exogenous cannabinoids and modulators (antagonists, transport inhibitors).
  • Utilized genetically altered animal models and measured endocannabinoid release.

Main Results:

Related Experiment Videos

  • Evidence from multiple research approaches converges.
  • Endocannabinoids are present in brain areas controlling pain sensitivity.
  • Modulating the endocannabinoid system affects pain sensitivity.

    • Conclusions:

    • Endocannabinoids function in pain control.
    • Their mechanism is parallel to, yet distinct from, endogenous opioids.