Related Experiment Video
Updated: Sep 30, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Genetic susceptibility to environmental toxicants: the interface between human and experimental studies in the
Ricarda Thier1, Klaus Golka, Thomas Brüning
1Institut für Arbeitsphysiologie an der Universität Dortmund (IfADo), Ardeystrasse 67, Germany. r.thier@mailbox.uq.edu.au
Abstract:
The growing knowledge of the genetic polymorphisms of enzymes metabolising xenobiotics in humans and their connections with individual susceptibility towards toxicants has created new and important interfaces between human epidemiology and experimental toxicology. The results of molecular epidemiological studies may provide new hypotheses and concepts, which call for experimental verification, and experimental concepts may obtain further proof by molecular epidemiological studies. If applied diligently, these possibilities may be combined to lead to new strategies of human-oriented toxicological research. This overview will present some outstanding examples for such strategies taken from the practically very important field of occupational toxicology. The main focus is placed on the effects of enzyme polymorphisms of the xenobiotic metabolism in association with the induction of bladder cancer and renal cell cancer after exposure to occupational chemicals. Also, smoking and induction of head and neck squamous cell cancer are considered.
More Related Videos
Related Concept Videos
Toxicity Testing in Animals
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Gene-Environment Interactions
Toxicokinetics: Overview
Drug Toxicity: Dose-Dependent Reactions
Mutagenicity and Carcinogenicity

