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Related Experiment Videos

Mass transfer correlations for rotating drum bioreactors.

Matthew T Hardin1, Tony Howes, David A Mitchell

  • 1Chemical and Materials Engineering Department, University of Auckland, Auckland, New Zealand. m.hardin@auckland.ac.nz

Journal of Biotechnology
|June 8, 2002
PubMed
Summary

Evaporative cooling in rotating drum bioreactors (RDBs) is crucial. This study determined the mass transfer coefficient for evaporation from wheat bran, finding a linear relationship with the effective Peclet number.

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Area of Science:

  • Biochemical Engineering
  • Mass Transfer Operations
  • Process Intensification

Background:

  • Evaporative cooling is critical for the efficient, large-scale operation of rotating drum bioreactors (RDBs).
  • Accurate mass transfer data is needed to optimize cooling and operational parameters in RDBs.
  • Wheat bran is a common substrate in bioreactors, making its evaporation characteristics important.

Purpose of the Study:

  • To determine the mass transfer coefficient (ka') for evaporation from a wet wheat bran bed to the headspace in an RDB.
  • To investigate the influence of aeration and rotation on evaporation.
  • To evaluate the impact of different gas-phase residence time distributions (RTDs) on ka' determination.

Main Methods:

  • Outlet water vapor concentrations were measured in an RDB containing wet wheat bran.

Related Experiment Videos

  • Mass transfer was quantified as ka' (mass transfer coefficient times area per unit void volume).
  • ka' was determined across various aeration velocities (0.006–0.017 ms⁻¹) and rotation rates (0–9 rpm), using plug flow, well-mixed, and Central Jet RTDs.

    • Main Results:

    • Values of ka' were determined under varying operational conditions.
    • Assuming plug flow led to an underestimation of ka' at low effective Peclet numbers (Pe(eff)).
    • ka' values derived using the Central Jet RTD correlated well with literature empirical correlations.
    • A linear correlation was established: ka' = 2.32 x 10⁻³ Pe(eff).

    Conclusions:

    • The Central Jet RTD model provides accurate mass transfer coefficients for RDBs.
    • The effective Peclet number is a key parameter influencing evaporative mass transfer in RDBs.
    • Accurate mass transfer data enables better design and control of evaporative cooling in RDBs.