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AMPA receptor trafficking and synaptic plasticity.

Roberto Malinow1, Robert C Malenka

  • 1Cold Spring Harbor Laboratory, New York 11724, USA. malinow@cshl.org

Annual Review of Neuroscience
|June 8, 2002
PubMed
Summary

Activity-dependent synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), relies on AMPA receptor trafficking. Specific receptor subunits and interacting proteins are crucial for these memory-related processes.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Synaptic plasticity, essential for memory formation, involves activity-dependent changes in neural connections.
  • Long-term potentiation (LTP) and long-term depression (LTD) are key mechanisms of synaptic plasticity.
  • The molecular underpinnings of LTP and LTD have been extensively investigated.

Purpose of the Study:

  • To review the literature on AMPA receptor trafficking in the context of LTP and LTD.
  • To highlight the roles of specific AMPA receptor subunits and their interacting proteins.
  • To provide a conceptual framework for understanding synaptic plasticity.

Main Methods:

  • Literature review of studies on AMPA receptor trafficking.
  • Analysis of research focusing on AMPA receptor subunits and associated proteins.
  • Synthesis of findings related to molecular mechanisms of synaptic plasticity.

Main Results:

  • AMPA receptor trafficking plays a critical role in both LTP and LTD.
  • Specific AMPA receptor subunits and their interacting proteins are integral to these plasticity mechanisms.
  • Evidence supports a significant contribution of receptor trafficking to synaptic strength modulation.

Conclusions:

  • AMPA receptor trafficking provides a unifying molecular framework for understanding LTP and LTD.
  • Further research into the molecular details of AMPA receptor trafficking will advance our understanding of memory formation.
  • This review consolidates current knowledge and directs future investigations in synaptic plasticity.

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