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Related Experiment Videos

Does renal dysfunction predict mortality after acute stroke? A 7-year follow-up study.

Ronald S MacWalter1, Suzanne Y S Wong, Kenneth Y K Wong

  • 1Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland. ronald.macwalter@tuht.scot.nhs.uk

Stroke
|June 8, 2002
PubMed
Summary
This summary is machine-generated.

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Reduced renal function after acute stroke predicts higher long-term mortality. Monitoring creatinine clearance and urea levels can help identify high-risk stroke patients for targeted interventions.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • Acute stroke is a leading cause of long-term disability and mortality.
  • Renal function is crucial for overall health and can be affected by various conditions, including stroke.
  • Assessing renal function post-stroke may offer insights into long-term prognosis.

Purpose of the Study:

  • To determine if renal function measured at hospital admission predicts long-term mortality in acute stroke patients.
  • To investigate specific renal function markers, such as creatinine clearance and serum urea levels, as prognostic indicators.
  • To explore the utility of renal function assessment in risk stratification for stroke survivors.

Main Methods:

  • A cohort study involving 2042 consecutive acute stroke patients admitted to a Scottish tertiary teaching hospital between 1988 and 1994.

Related Experiment Videos

  • Follow-up extended up to 7 years, with all-cause mortality as the primary outcome measure.
  • Renal function was assessed using serum creatinine, urea levels, and calculated creatinine clearance, analyzed via Cox proportional-hazards models.

    • Main Results:

    • A total of 1026 deaths were recorded during the follow-up period.
    • Lower calculated creatinine clearance and higher serum creatinine, urea, and urea-to-creatinine ratio were associated with increased mortality.
    • Calculated creatinine clearance >= 51.27 mL/min was a significant predictor of better long-term survival, even after adjusting for confounders.

    Conclusions:

    • Reduced admission calculated creatinine clearance, elevated serum creatinine and urea, and an increased urea-to-creatinine ratio are associated with higher mortality risk after acute stroke.
    • These renal function markers can aid in identifying patients at increased risk of long-term mortality.
    • Findings suggest potential for targeted interventions, such as angiotensin-converting enzyme inhibitors, in high-risk stroke patients based on renal function assessment.