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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Maternal peripheral T-helper 1-type and T-helper 2-type immunity in nonpreeclamptic twin pregnancies

Shunji Suzuki1, Toyohiko Kuwajima, Yoshio Yoneyama

  • 1Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.

Gynecologic and Obstetric Investigation
|June 8, 2002
PubMed

The percentage of T-helper (Th)1, Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 14 normal nonpregnant women, 23 normal pregnant women and 9 patients with twin pregnancies without preeclampsia at 28-32 weeks' gestation were calculated using flow cytometry. In normal pregnant women, the percentage of Th1 cells and Th1:Th2 ratios were significantly lower than those in nonpregnant women. In twin pregnancies, the percentage of Th1 cells and the Th1:Th2 ratios were significantly lower than those in non-pregnancies. In twin pregnancies; in addition, the percentage of Th1 cells was significantly lower than that in singleton pregnancies. Our findings show a markedly predominant Th2 immunity in twin pregnancies.

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