Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Connexins and gap junctions in the inner ear.

Andrew Forge1, David Becker, Stefano Casalotti

  • 1UCL Centre for Auditory Research and Institute of Laryngology and Otology, UCL, London, UK. a.forge@ucl.ac.uk

Audiology & Neuro-Otology
|June 8, 2002
PubMed
Summary

Mutations in connexin genes cause deafness, highlighting the role of gap junctions in hearing. Researchers studied connexin expression and mutation effects in the inner ear to understand these structure-function relationships.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Board review of forensic and medical ethics proceedings initiated against doctors in Hungary (2024-2025)].

Orvosi hetilap·2026
Same author

Simplified radial artery haemostasis: using non-compressive dressings-the Radial Artery Puncture Haemostasis Evaluation trial: results of the RAPHE trial.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

The Development and Implementation of Administrative Time to Improve Resident Physician Compliance.

Journal of graduate medical education·2026
Same author

Pediatric Diabetes Prevalence Among Medicaid Beneficiaries.

JAMA network open·2026
Same author

[Recanalization of chronic total coronary occlusion via transradial access].

Orvosi hetilap·2026
Same author

[Physical activity during pregnancy and the postpartum period: recreational and competitive sport].

Orvosi hetilap·2025

Area of Science:

  • Neuroscience
  • Genetics
  • Cell Biology

Background:

  • Gap junctions are crucial for cell-to-cell communication.
  • Mutations in connexin genes are linked to various forms of inherited deafness.
  • Understanding connexin function is vital for auditory health.

Purpose of the Study:

  • To investigate the role of gap junctions in auditory function.
  • To explore structure-function relationships of connexin proteins.
  • To analyze the impact of specific connexin mutations on protein processing and function.

Main Methods:

  • Examining gap junction distribution in the mature and developing inner ear.
  • Analyzing connexin gene expression patterns.
  • Utilizing an in vitro system to study the effects of mutations on connexin protein processing and functionality.

Related Experiment Videos

Main Results:

  • Connexin mutations are associated with deafness, confirming their role in auditory function.
  • Gap junctions are present in the mature inner ear and their expression changes during development.
  • Specific mutations affect connexin protein processing and function in vitro.

Conclusions:

  • Gap junctions play a critical role in hearing.
  • Connexin structure and function are intrinsically linked.
  • Further research into connexin mutations can inform strategies for addressing deafness.