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Changes in coagulation factors and platelet function in response to progestational agents.

K M McGrath, P A Castaldi

    Haemostasis
    |January 1, 1975
    PubMed
    Summary

    Oral contraceptives significantly increase coagulation factors II, V, VII-X, X, and plasminogen activity, alongside enhanced collagen-induced platelet aggregation. Antithrombin III levels remained unchanged in study participants.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Pharmacology

    Background:

    • Oral contraceptive agents are widely used for birth control.
    • Hormonal contraceptives can influence hemostasis and thrombosis risk.
    • Understanding the impact of oral contraceptives on coagulation factors is crucial.

    Purpose of the Study:

    • To investigate the effects of oral contraceptive agents on specific coagulation factors and platelet aggregation.
    • To compare hemostatic parameters between oral contraceptive users and a control group.

    Main Methods:

    • Measurement of coagulation factors I, II, V, VII-X, VIII, IX, X, plasminogen, and antithrombin III activity at midcycle.
    • Immunoassay for factor II and antithrombin III antigen levels.
    • Quantitative assessment of platelet aggregation induced by collagen.

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    Main Results:

    • Significant increases in the activity of coagulation factors II, V, VII-X, X, and plasminogen were observed in oral contraceptive users.
    • Factor II antigen levels showed no significant change.
    • Platelet aggregation with collagen was significantly enhanced.
    • Antithrombin III activity and antigen levels remained unchanged.

    Conclusions:

    • Oral contraceptive use is associated with increased activity of several key procoagulant factors and enhanced platelet aggregation.
    • These hemostatic changes may contribute to the thrombotic risk associated with oral contraceptives.
    • Antithrombin III levels are not affected by oral contraceptive use.