Related Experiment Videos

[Pancreatic involvement in inflammatory bowel diseases in children]

C Le Large-Guiheneuf1, J P Hugot, C Faure

  • 1Service de gastroentérologie et nutrition pédiatriques, hôpital Robert-Debré, 48, Bd Sérurier 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 11, 2002
PubMed

Insights

Pancreatitis occurs in 27% of children with inflammatory bowel disease (IBD), affecting girls more often. Regular monitoring is crucial due to multifactorial causes, including medications.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Internal Medicine

Context:

  • Pancreatitis in pediatric inflammatory bowel disease (IBD) is not well-documented.
  • Adult IBD patients experience symptomatic pancreatitis in 2% and asymptomatic in 8-21%.

Purpose:

  • To retrospectively review the frequency of pancreatitis in pediatric IBD patients.
  • To identify risk factors and associations of pancreatitis in children with IBD.

Summary:

  • This study found pancreatitis in 27% of 124 pediatric IBD patients (14.5% symptomatic, 12.5% asymptomatic).
  • Pancreatitis was more common in girls and associated with active, severe IBD, certain medications (azathioprine, 5-ASA, salazopyrin), duodenal Crohn's disease, and hepatobiliary complications.
  • Symptomatic pancreatitis was typically moderate, uncomplicated, and recurrent.

Impact:

  • Highlights the high incidence of pancreatitis in pediatric IBD.
  • Emphasizes the need for regular pancreatitis monitoring in children with IBD.
  • Suggests multifactorial causes and the importance of accurate diagnosis to avoid misattributing drug-induced pancreatitis.
Abstract

Related Concept Videos

Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...