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Published on: February 17, 2022
Clinical issues in the administration of an anti-epidermal growth factor receptor monoclonal antibody, IMC-C225
1Department of Gastrointestinal Medical Oncology, Memorial Sloan-Kettering Hospital, 504 East 63rd St-28 N, New York, NY 10021, USA.
Objectives:
To review the clinical safety experience of the monoclonal antibody IMC-C225, focusing on two clinically important adverse events: acne-like rash and allergic reactions. In addition, practical administration issues are discussed.
Data Sources:
Research articles.
Conclusions:
IMC-C225 administration is well tolerated and adverse events are mild and manageable. IMC-C225 can be safely and conveniently administered once weekly in outpatient settings.
Implications For Nursing Practice:
Because nurses will be involved with administration of IMC-C225 in the clinical setting, they must understand and be prepared to manage the acute and long-term adverse events associated with this agent.