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Neuroendocrine tumors of the lung: recent developments in histopathology
1Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences, New York Presbyterian Hospital, New York, New York 10021, USA. dbf2001@mail.med.cornell.edu
Abstract:
Lung tumors with neuroendocrine differentiation are made up of several neoplasms with particular epidemiologic, clinical, morphologic, and molecular characteristics. Typical and atypical carcinoid tumors represent low-grade and intermediate-grade carcinomas, respectively, whereas small-cell carcinoma and large-cell neuroendocrine carcinoma are considered high-grade carcinomas. Recent studies support the use of this four-tumor, three-tier classification scheme, but in practice, definitive diagnoses on small tissue samples remain a challenge for even the most experienced lung pathologists.