Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Monophasic action potentials: considerations and limits].

J M Davy1, Ch Piot, L Beck

  • 1Service de cardiologie B, hôpital Arnaud de Villeneuve, CHU de Montpellier, avenue du Doven Gaston Giraud, 34295 Montpellier.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|June 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution to unravel variability in bowhead whale songs and better understand its ecological significance.

Scientific reports·2021
Same author

Measurement of associated Z + charm production in proton-proton collisions at <math> </math> <math></math>.

The European physical journal. C, Particles and fields·2019
Same author

Search for new physics in events with a leptonically decaying Z boson and a large transverse momentum imbalance in proton-proton collisions at <math></math> = 13 <math></math>.

The European physical journal. C, Particles and fields·2019
Same author

Measurement of exclusive <math></math> photoproduction from protons in <math></math> Pb collisions at <math> </math>.

The European physical journal. C, Particles and fields·2019
Same author

Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2019
Same author

Search for resonant production of second-generation sleptons with same-sign dimuon events in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2019
Same journal

Radiokymographic study of the kinetics of the middle arc and the hils in the normal subject.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

A medication for angina pectoris and pre-fibrillatory conditions; 1262 F; six years of clinical experience; action mechanism.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Circulatory changes following the injection of hypertonic saline solutions; application to the study of angina pectoris.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Alterations in coronary circulation during aortic insufficiency in young subjects.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Cardio-esophageal auscultation.

Archives des maladies du coeur et des vaisseaux·2010
Same journal

Hypertensive accidents following the injection of acetylcholine.

Archives des maladies du coeur et des vaisseaux·2010
See all related articles

Monophasic action potentials (MAPs) offer continuous in vivo analysis of cardiac repolarization, aiding study of arrhythmias like fibrillation. However, their use in studying premature post-depolarizations is questionable due to signal summation.

Area of Science:

  • Electrophysiology
  • Cardiovascular Research

Context:

  • Monophasic action potentials (MAPs) are extracellular currents mirroring intracellular action potentials.
  • Historically challenging to record, MAPs now require firm myocardial contact and specific filters (excluding high-pass).

Purpose:

  • To review the utility and limitations of MAP recordings in cardiovascular research.
  • To highlight applications in studying action potential duration, cellular topography, and polymorphic arrhythmias.
  • To critically assess the application of MAPs in the study of premature post-depolarizations.

Summary:

  • MAPs provide continuous in vivo repolarization signals, useful for analyzing action potential duration and polymorphic arrhythmias (e.g., atrial fibrillation, ventricular fibrillation).
  • Precise beat-to-beat refractory period measurement is limited during polymorphic arrhythmias.

Related Experiment Videos

  • MAPs are considered unsuitable for studying premature post-depolarizations due to their summative nature, reflecting multiple cells.

    • Impact:

    • Facilitates continuous in vivo monitoring of cardiac electrophysiology.
    • Provides insights into mechanisms of polymorphic arrhythmias.
    • Clarifies the limitations of MAP recordings in specific arrhythmia research, guiding future studies.