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[Chrysiasis].

K Loddenkemper¹, F Buttgereit

¹Universitätsklinikum Charité Berlin Innere Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie Schumannstr. 20-21, 10117 Berlin, Germany. konstanze.loddenkemper@charite.de

Zeitschrift Fur Rheumatologie

|June 12, 2002

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Chrysiasis, a rare skin pigmentation, can occur after long-term gold injections for rheumatoid arthritis. The exact causes of this permanent gold-induced skin discoloration are still being investigated.

Area of Science:

Dermatology
Rheumatology
Toxicology

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease.
Parenteral gold therapy was historically used for RA management.
Chrysiasis is a known but uncommon adverse effect of gold treatment.

Observation:

A 78-year-old woman with RA presented with chrysiasis.
The patient had received 3 years of regular parenteral gold administration.
Chrysiasis manifested as permanent skin pigmentation.

Findings:

The case highlights a link between prolonged gold therapy and skin discoloration.
Chrysiasis is a permanent, gold-induced dermatological condition.
The etiology of chrysiasis is multifactorial and not fully elucidated.

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Implications:

Understanding chrysiasis is crucial for managing long-term gold therapy side effects.
Further research is needed to fully establish the multifactorial causes of chrysiasis.
This case contributes to the literature on iatrogenic skin pigmentation.