Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Callosal function in multiple sclerosis: bimanual motor coordination.

Eric B Larson1, Debra S Burnison, Warren S Brown

  • 1Travis Research Institute, Fuller Graduate School of Psychology, USA. elarson@rehabchicago.org

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|June 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same author

Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology.

JAMA network open·2026
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

medRxiv : the preprint server for health sciences·2026
Same author

Aesthetic judgement and appreciation in agenesis of the corpus callosum.

Neuropsychologia·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

The cognitive construction of moral scenes: Associations of visuospatial ability and impulsivity with perspective and vividness in mental simulation.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Theta band activity during event-file retrieval is influenced by stimulus salience in the preceding action episode.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Language recovery in Hungarian speakers with aphasia: Roles of phonology and intraindividual variability.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Neural and behavioral dissociations of self-focused and other-focused incentives in trust.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same journal

Reading and writing impairments in Spanish-speaking individuals with primary progressive aphasia: A single-case series study.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
See all related articles

Multiple sclerosis (MS) patients show impaired bimanual coordination due to callosal dysfunction. This deficit in interhemispheric motor interactions is linked to inefficient callosal transmission, impacting motor control in MS.

Area of Science:

  • Neuroscience
  • Neurology
  • Motor Control

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Callosal dysfunction is increasingly recognized as a contributor to neurological deficits in MS.
  • Understanding the impact of callosal dysfunction on motor coordination is crucial for MS patient care.

Purpose of the Study:

  • To investigate evidence of callosal dysfunction in MS patients using a bimanual coordination test.
  • To determine if deficits in bimanual motor coordination are associated with callosal dysfunction in MS.

Main Methods:

  • Utilized the Bimanual Coordination Test (BCT) to assess motor speed and intermanual coordination in MS patients and controls.
  • Compared performance on unimanual and bimanual trials to identify coordination deficits.

Related Experiment Videos

  • Correlated motor coordination deficits with prior identification of inefficient callosal transmission via evoked potentials (EPs).

    • Main Results:

    • MS patients were significantly slower than non-patients on both unimanual and bimanual coordination tasks.
    • MS patients showed a greater difference between bimanual and unimanual response times, indicating impaired interhemispheric communication.
    • The deficit in bimanual coordination was specifically observed in MS patients with evidence of inefficient callosal transmission (abnormal EPs).

    Conclusions:

    • Deficits in bimanual motor coordination are present in patients with multiple sclerosis.
    • These motor coordination deficits are directly related to callosal dysfunction and inefficient interhemispheric communication.
    • Evoked potential measures can identify MS patients with callosal dysfunction who are susceptible to bimanual coordination impairments.