Related Experiment Videos
Spotlight on almotriptan in migraine
Susan J Keam1, Karen L Goa, David P Figgitt
1Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz
CNS Drugs
|June 12, 2002
Summary
Almotriptan effectively treats moderate to severe migraine attacks in adults, offering rapid relief and sustained efficacy. This selective serotonin receptor agonist demonstrates comparable effectiveness to sumatriptan with a favorable safety profile, including less chest pain.
Area of Science:
- Neurology
- Pharmacology
- Clinical Trials
Background:
- Migraine is a common neurological disorder characterized by moderate to severe attacks.
- Selective serotonin 5-HT(1B/1D) receptor agonists, known as triptans, are used for acute migraine treatment.
- Almotriptan is one such agent evaluated for its efficacy and tolerability.
Purpose of the Study:
- To assess the efficacy and tolerability of oral almotriptan in adults with moderate or severe migraine attacks.
- To compare almotriptan's effectiveness and safety profile against placebo and sumatriptan.
Main Methods:
- Conducted multiple randomized, controlled trials involving over 4800 adult patients.
- Evaluated parameters such as 2-hour headache response, pain-free response, and alleviation of associated migraine symptoms.
- Assessed long-term efficacy and tolerability over repeated doses and up to one year of treatment.
Main Results:
- Oral almotriptan demonstrated rapid onset of action, with significant headache relief observed at 0.5 hours.
- Efficacy was sustained, and almotriptan proved significantly more effective than placebo.
- Almotriptan showed similar efficacy to sumatriptan for single attacks and was associated with a lower incidence of chest pain and comparable overall tolerability.
Conclusions:
- Almotriptan is an effective option for the acute treatment of moderate to severe migraine in adults.
- Its efficacy is comparable to sumatriptan and maintained long-term, with a good safety and tolerability profile.
- Almotriptan represents a potentially valuable addition to the available treatment options for migraine management.