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Related Concept Videos

Local Attraction01:22

Local Attraction

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Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
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Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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Renal Clearance01:23

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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
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Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

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Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
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Drug Elimination: Non-Renal Routes01:23

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The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
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Localized renal cell carcinoma.

P Russo1

  • 1Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. RussoP@MSKCC.org

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|June 12, 2002
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This summary is machine-generated.

Advances in abdominal imaging have led to incidental discovery of localized renal tumors. Surgical options now prioritize kidney function preservation alongside tumor removal, improving survival rates.

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Area of Science:

  • Urology
  • Oncology
  • Radiology

Background:

  • Abdominal imaging (CT, MRI, ultrasound) has improved, leading to incidental discovery of renal tumors in most patients.
  • This shift to earlier detection has significantly improved survival rates for localized renal tumors, with over 75% cure rates after surgery.
  • The increased detection of small, incidental tumors has expanded therapeutic options, emphasizing renal function preservation.

Purpose of the Study:

  • To review the evolving understanding of localized renal tumors.
  • To discuss the impact of improved imaging on tumor detection and patient outcomes.
  • To explore current and emerging surgical and ablative techniques for renal tumors.

Main Methods:

  • Review of advancements in abdominal imaging modalities.
  • Analysis of surgical and therapeutic options for localized renal tumors.
  • Discussion of histological subtypes and their varying metastatic potentials.

Main Results:

  • Incidental discovery of renal tumors is now common, improving survival rates.
  • Renal tumors are a complex family of neoplasms with diverse subtypes and metastatic potentials.
  • Surgical approaches range from radical nephrectomy to kidney-sparing techniques and laparoscopy.

Conclusions:

  • Localized renal tumors are increasingly detected incidentally, improving prognosis.
  • Renal tumor management now balances local control with renal function preservation.
  • New ablative techniques are under investigation and may supplement or replace current surgical methods.