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Penicillin-binding proteins 1a and 1b form independent dimers in Escherichia coli
Xavier Charpentier1, Christian Chalut, Marie-Hélène Rémy
1Institut de Pharmacologie et de Biologie Structurale, UMR 5089 du CNRS. Institut National des Sciences Appliquées de Toulouse, Toulouse, France.
Journal of Bacteriology
|June 12, 2002
Abstract:
We report here that PBP1a can dimerize but does not interact with PBP1b to form PBP1a/PBP1b heterodimers in Escherichia coli. These findings support the idea of a relevant involvement of dimerization of both PBP1a and PBP1b during murein synthesis and suggest the existence of different peptidoglycan synthesis complexes.