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Candida species isolated from cerebrospinal fluid
E Dorko1, E Pilipcinec, L Tkáciková
1Department of Physiology, Faculty of Medicine, Safárik University, 040 66 Kosice, Slovakia.
Folia Microbiologica
|June 13, 2002
Summary
Nosocomial meningitis cases were analyzed, with Candida albicans being the most common cause (54%). This study highlights the prevalence of Candida species in hospital-acquired meningitis, particularly in vulnerable patient groups.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Hospital Epidemiology
Background:
- Nosocomial meningitis poses a significant threat in healthcare settings.
- Fungal meningitis, particularly Candida-related, requires specific diagnostic and treatment considerations.
Purpose of the Study:
- To investigate the incidence and species distribution of Candida in nosocomial meningitis cases.
- To identify patient populations at higher risk for fungal meningitis.
Main Methods:
- Retrospective analysis of 13 nosocomial meningitis cases reported between November 1998 and June 2001.
- Microbiological examination of cerebrospinal fluid (CSF) and other relevant samples for Candida species identification.
Main Results:
- Candida albicans was the predominant species, isolated from 54% of patients.
- Other identified species included C. parapsilosis (23%), C. tropicalis (15%), and C. krusei (8%).
- Candida was frequently isolated from CSF in pediatric patients with central nervous system disorders, sepsis, or prematurity, and in adults post-neurosurgery or with cerebrovascular disease.
Conclusions:
- Candida species, especially C. albicans, are significant causative agents of nosocomial meningitis.
- Vulnerable populations including neonates, children with CNS conditions, and post-neurosurgical adults are at increased risk.