Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Organometallic chemistry on solid phase. An overview.

Gianna Reginato1, Maurizio Taddei

  • 1CNR, Istituto di Chimica dei Composti Organo Metallici, Departimento di Chimica Organica Ugo Schiff, Polo Scientifico, Università degli Studi di Firenze, Sesto Fiorentino, Italy. gianna.reginato@unifi.it

Farmaco (Societa Chimica Italiana : 1989)
|June 13, 2002
PubMed
Summary

Solid-phase organic synthesis (SPOS) enables combinatorial library production. This review highlights recent advances in using organometallic reagents for carbon-carbon bond formation in SPOS, expanding its synthetic utility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural products as payloads for antibody-drug conjugates: Cyclopamine linked to cetuximab for hedgehog pathway inhibition.

Bioorganic chemistry·2026
Same author

ProTide-enabled antibody-drug conjugates: A novel platform for the targeted delivery of phosphorylated drugs.

Bioorganic chemistry·2025
Same author

Drug enteric metabolism in gut microbiota-brain crosstalk.

Life sciences·2025
Same author

Fluoromethylcarnitine, a novel inhibitor of trimethylamine levels in trimethylaminuria and trimethylamine N-oxide related disorders.

European journal of medicinal chemistry·2025
Same author

Improved light harvesting <i>via</i> energy transfer within a benzothiadiazole-based antenna-sensitizer dyad for dye-sensitized solar cells.

Chemical communications (Cambridge, England)·2025
Same author

Pd-Catalyzed Miyaura Borylation and Telescopic Borylation/Suzuki-Miyaura Cross-Coupling Processes in Deep-Eutectic Solvents.

The Journal of organic chemistry·2024

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry

Background:

  • Solid-phase organic synthesis (SPOS) is crucial for generating combinatorial libraries used in pharmaceutical and agricultural research.
  • The application of organometallic reagents for carbon-carbon bond formation in SPOS has been underexplored.
  • High-throughput screening has increased the demand for diverse chemical libraries.

Purpose of the Study:

  • To provide an overview of recent advancements in utilizing organometallic reagents for carbon-carbon bond formation within solid-phase organic synthesis.
  • To highlight the scope and limitations of various organometallic reagents in SPOS.
  • To identify trends and potential future directions in this synthetic methodology.

Main Methods:

  • Review of recent literature focusing on the use of organometallic reagents (Li, Mg, Cu, Zn, Si, B) in SPOS for C-C bond formation.

Related Experiment Videos

  • Exclusion of palladium-catalyzed cross-coupling reactions from the scope of the review.
  • Analysis of the compatibility of different organometallic reagents with various solid supports and reaction conditions.

    • Main Results:

    • Organolithium and organomagnesium reagents have been more frequently employed than cuprates and zincates in SPOS.
    • The successful application of highly basic organometallics suggests the robustness of certain resin supports under demanding reaction conditions.
    • Recent examples demonstrate the growing potential of organometallic reagents for C-C bond formation on solid phase.

    Conclusions:

    • Organometallic reagents offer a valuable, albeit underexplored, avenue for expanding the synthetic capabilities of solid-phase organic synthesis.
    • The choice of organometallic reagent and resin support is critical for successful C-C bond formation in SPOS.
    • Further research into organometallic chemistry on solid phase holds significant promise for accelerating drug discovery and agricultural chemistry.